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Jan 28, 2020 · The development of more targeted MPO inhibitors, or a treatment regime designed to reduce MPO-associated host tissue damage without compromising pathogen killing by the innate immune system are important future directions. SIGNIFICANCE Release of myeloperoxidase (MPO) by activated leukocytes is critical in innate immune responses. MPO produces hypochlorous acid (HOCl) and other strong oxidants

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Prognostic Role of Elevated Myeloperoxidase in Patients with Prognostic Role of Elevated Myeloperoxidase in Patients

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Meteorology and Physical Oceanography (MPO) - University of Miami, Abstract. Microscopic polyangiitis (MPA) is an ANCA-associated vasculitis that affects small vessels, especially renal glomeruli. We recently demonstrated that the abnormal formation and impaired degradation of neutrophil extracellular traps (NETs) may be crucially involved in the generation of myeloperoxidase (MPO)-ANCA and subsequent development.

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